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The higher incidence of hepatictoxicity in fast acetylators was thought to be due to the morerapid formation of acetylisoniazid that underwent hydro-lysis to acetylhydrazine, which could be metabolized (byCYP2E1) to acetyldiazine and thence an acetylcarboniumion that could form covalent adducts with cellular componentsand result in cell death. The lysosomal membranehas an unusual phospholipid structure that contains cholesteroland a unique lipid called lysobisphosphatidic acid. Activation of the NF-kB pathway is responsible forthe activation of these lymphokine genes through direct contact with their promoters.
Levodopa-induceddyskinesias were noted in 4% of the 103 cases of PSP thatthey described. However, complete resection has been achievedin 29% of patients with apparent extension to lateral pelvic wall with a 32% 10-yearsurvival rate.3 In some patients, fixation to the pelvic wall is secondary to radiationfibrosis and the recurrence can be easily resected. Each vesicle consistsofa single tube folded and coiled on itselfwith occasional diverticula inits wall. You cannoteven give aspirin without doing a head CT first. Most epidemio-logic data relate to VaD, with rates approximating half thoseof AD. (2007) VBM signa-tures of abnormal eating behaviours in frontotemporal lobardegeneration. The rate of vocalizationsper minute that included a consonant was 1.14(SD= 1.22).
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